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We're so glad Sadie was chosen for a part in the Vet-Stem research project. She's doing so much better, getting up steps great, and even getting on her brother's bed unassisted! She's in much greater spirits and really enjoyed her walk with us around the cotton fields. You helped a "miracle" happen! Thanks.

Sharon Raynor
Tarboro, NC





Potential Future Applications
Fortier LA, Nixon AJ, Williams J, Cable CS: Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. AJVR 59:1182-1187, 1998.

Frisbie DD, McIlwraith CW: Gene Therapy: Future Therapies in Osteoarthritis. In: 2001 AAEP, pp 211-216, 2001.

Im G-I, Kim D-Y, Shin J-H, Hyun C-W, Cho W-H: Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow. J Bone and Joint Surgery 83-B:289-294, 2001.

Johnstone B: Tissue Engineered Meniscus Repair. Cleveland, Case Western Reserve University, 2002.

Jorgensen C, Noel D, Apparailly F, Sany J: Stem cells for repair of cartilage and bone: the next challenge in osteoarthritis and rheumatoid arthritis. Ann Rheum Dis 60:305-309, 2001.

Lu X, Li S, Cheng J: Bone marrow mesenchymal stem cells: progress in bone/cartilage defect repair. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 19:135-139, 2002.

Nixon AJ: Use of Stem Cells for Cartilage Repair to Combat Arthritis and Stress-Induced Breakdown. Ithaca, Cornell University College of Veterinary Medicine (ongoing study).

Quintavalla J, Uziel-Fusi S, Yin J, Boehnlein E, Pastor G, Blancuzzi V, Singh HN, Kraus K, O'Byrne E, Pellas TC: Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. Biomaterials:109-119, 2002.

Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg V: Mesenchymal Cell-Based Repair of Large, Full-Thickness Defects of Articular Cartilage. J Bone and Joint Surgery 76-A:579-592, 1994.